cGP-PRo® is not marketed or sold to consumers. All information contained on this website is provided for scientific research and product development purposes
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is a dipeptide that plays a crucial role in regulating Insulin-like Growth Factor-1 (IGF-1), a hormone essential for growth, development, metabolism, neuroprotection, and cell survival.
IGF-1 performs many biological functions across our lifespan. One of its key functions is maintaining healthy blood circulation. Having robust circulation is vital for healthy functioning of our tissues and organs.
Our IGF-1 levels naturally begin to decline around age 45 or can occur prematurely because of an unhealthy lifestyle, ongoing stressors, and the onset of some health conditions.
Years of extensive research by our Chief Science Officer and scientists globally, have shown the importance of maintaining IGF-1 activity for positive health outcomes as we age.
cGP acts as a key regulator of IGF-1 activity by interacting with its binding proteins. Normally, these proteins bind to IGF-1, making IGF-1 inactive. However, cGP competes for the same binding proteins, freeing IGF-1 and allowing it to become biologically active when needed. Hence, cGP is an important part of maininting health and vitality through its actions on IGF-1.
WHAT IS IGF-1?
IGF-1 (insulin-like growth factor 1) is a hormone that plays an important role in managing and promoting normal growth and development in the human body. Its function as a neurotrophic factor in the brain, makes it essential for brain development and cognitive function.
In addition, IGF-1 also helps with other important processes in the body such as energy metabolism, and wound healing making it a life-essential hormone.
THE PHYSIOLOGICAL IMPACT OF IGF-1
IGF-1 is primarily secreted by the liver and is transported to other tissues, acting as an endocrine hormone. Although it is mainly produced by the liver, several other tissues are also able to secrete IGF-I for autocrine/paracrine purposes; including muscles, bones, and fat cells, where it can act locally to support growth and repair across various stages of life.
IGF-1 function declines with age which can contribute to cardiovascular ageing, declining metabolic health as well as cerebrovascular diseases such as stroke, hypertension, and cognitive impairment.
IGF-1 IN THE DIFFERENT STAGES OF LIFE
IGF-I levels are maximal during peripubertal growth and early adult hood; however, they progressively decline with age. Reduced IGF-I levels in the elderly contribute to age-related symptoms and subsequently, progression of age-related neurological conditions. Maintaining optimal IGF-1 levels and function is important across life-stages especially after the age of 45.
HOW DOES IGF-1 WORK IN THE BODY?
In the bloodstream, IGF-1 remains bound to ‘binding proteins’ in its inactivated form. In order to be functional, IGF-1 breaks this bond with the ‘binding proteins’ and is activated by its receptors. These receptors are present on cells throughout the body, including bone, muscle, and fat cells, as well as cells in the brain and other organs which allows IGF-1 to execute its function.
IGF-1 helps to produce/re-generate small blood vessels (capillaries) in our body which is crucial as it aids in the transportation of nutrients throughout your body and helps in taking away toxic waste from tissues and organs. IGF-1 stimulates cell growth and division, as well as the production of new cells. It also plays a key role in regulating metabolism, helping to maintain healthy levels of oxygen and other nutrients in the blood. In addition to its role in growth and development, IGF-1 is also involved in the repair and maintenance of tissues throughout the body.
WHAT IS CGP?
cGP (cyclic-Glycine-Proline) is a molecule that our body produces by itself and is a key player in regulating the IGF-1 activation/inactivation. It works by normalising the IGF-1 function and is crucial for the normal growth of humans, neurological development and improving the brain signalling pathways.
THE IMPORTANCE OF CGP
As we get older, our requirement for cGP increases, while our bodies simply cannot make enough cGP to meet these demands. Thus, pointing to an increased need for cGP supplementation as we age.
BENEFITS OF cGP FOR BRAIN DEVELOPMENT AND NEUROPROTECTION
cGP plays a vital role in regulating Insulin-Like Growth Factor-1 (IGF-1), a hormone essential for maintaining overall health. Factors such as ageing, stress, and poor lifestyle choices can reduce IGF-1 levels, increasing the body's demand for cGP. When cGP levels are insufficient, IGF-1 cannot function properly, which has been linked to neurodegenerative conditions like Parkinson’s disease, Alzheimer’s disease, and dementia.
cGP supports the repair and remodeling of small blood vessels, helping to restore connections in the brain and improve nutrient delivery throughout the body. This contributes to better cognitive function, enhanced focus, mental clarity, improved sleep, higher energy levels, and a more balanced mood. Supplementing with cGP may help slow the progression of neurodegenerative diseases and support long-term brain health, ultimately improving overall quality of life.
BLOOD VESSELS - THE VEINS, THE ARTERIES, AND CAPILLARIES
Blood vessels circulate blood throughout your body delivering nutrients to vital organs and tissues, and also help with taking metabolic waste away. Blood vessels include veins, arteries and capillaries.
There are three types of blood vessels:
CAPILLARIES
The smallest blood vessels, connect arteries and veins and are responsible for facilitating the exchange of various substances between bloodstream and tissues/organs. This exchange is crucial as it includes delivering nutrients and oxygen to tissues/organs to ensure their health and function and also includes clearing of waste from tissues/organs to avoid the build-up of plaques and obstruction of blood flow.
ARTERIES
Carry blood away from your heart
VEINS
Carry blood back towards your heart