2023 Guan J, Li Fx, Kang D, Anderson T, Pitcher T, Dalrymple-Alford J, Shorten P and Singh-Mallah G, Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions. Molecules 10.3390/molecules28031021.
2016 Costales J, and Kolevzon A, The Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders. Neurosci Biobehav Rev. 63: 207–222. doi:10.1016/j.neubiorev.2016.01.001.
2014 Guan J, Gluckman PD, Yang PZ, Krissansen G, Sun K, Zhou Y, Wen JY, Shorten P, Wake G, Mcmahon CD, Thomas MF, Philip G, Chen W, S Moon, A Ren and Liu DX, Cyclic Glycine-Proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1. Scientific Report, 4, 4388.
2012 Juan E Puche and Inma Castilla-Cortázar Human conditions of insulin-like growth factor-I (IGF-I) deficiency. Journal of Translational Medicine, 10:224
2025 Zhu M, Li F, Huang S, Huang L, Zhang H, Chen L, Cave V, Guan J, Yang Y. Plasma concentration of cyclic glycine proline is associated with impaired energy metabolism in a Chinese population of type 2 diabetes mellitus. Endocrine and Metabolic Science, 17: 2025 025,100219,ISSN 2666-3961 https://doi.org/10.1016/j.endmts.2025.100219
2019 Li FX, Liu K, Gray C, Harris P, Reynolds C, Vickers M and Guan J. Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats. Nutrition, Metabolism & Cardiovascular Diseases. 30: 339-346.
2019 Li FX, Liu K, Wang A, Harris P, Vickers M and Guan J. Cyclic Glycine-Proline Administration Normalizes High-Fat Diet-Induced Synaptic Expressions in Obese Rats. Neuropeptides 76, 101935, 10.1016/j.npep.2019.05.006.
2021 Kang D, Waldvogel H, Fan D, Wang A, Faull R, Curtis M, Shorten P and Guan J. The autocrine regulation in human brain of Alzheimer’s diseases. Psychoneuroendocrinology, 2021 May;127:105191. doi: 10.1016/j.psyneuen.2021.10519.
2020 Fan D, Pitcher T, Dalrymple-Alford J, MacAskill M, Anderson T and Guan J. Plasma cGP/IGF-1 molar ratio is associated with cognitive status of Parkinson disease. Alzheimer’s Dement. 2020;1–10. https://doi.org/10.1002/dad2.12025
2019 Fan D, Krishnamurthi R, Harris P, Barber PA, Guan J. Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients. Ann Clin Transl Neurol 2019;0. doi:10.1002/acn3.743.
2018 Fan D, Alamri Y, Liu K, MacAskill M, Harris P, Brimble M, et al. Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function. Nutrients 2018;10:714. doi:10.3390/nu10060714.
2017 Yang P, Waldvogel H, Scott E, Faull R, Dragunow M, Turner C, and Guan J. Endothelial degeneration of Parkinson disease is related to alpha-synuclein aggregation. Journal of Alzheimer’s Disease & Parkinsonism 7: 370. doi: 10.4172/2161-0460.1000370.
2017 Yang P, Waldvogel H, Faull R, Dragunow M, Turner C, and Guan J. Vascular remodelling is impaired in Parkinson’s diseases. Journal of Alzheimer’s Disease & Parkinsonism 7: 313. doi: 10.4172/2161-0460.1000313.
2016 Guan J, Yang P, Turner C, Nicholson LFB, Faull R, Dragunow M and Waldvogel H Vascular degeneration of Parkinson diseases. SciRes Alzheimer’s and Parkinson’s Diseases 2016;1(1): 013-017
2015 Guan J, Harris P, Brimble M, Lei Y, Lu J, Yang Y and J Gunn A, The role for IGF-1 derived small neuropeptides as a therapeutic target for neurological disorders. Expert Opinion on Therapeutic Targets. Invited review 2015 Feb 5:1-9
2014 Mathai S, Gunn AJ, Brimble MA, Harris PW and Guan J. Neuroprotection with Glycin-2methyl-Proline-Glutamate (G-2mPE) after hypoxic-ischemic brain injury in adult rats. Journal of Experimental Stroke Translational Medicine 6: 1-11
2013 Guan J, Matai S, Liang HP and Gunn JA Insulin-like growth factor-1 and its derivatives: Potential pharmaceutical application for treating neurological conditions. Recent Patents on CNS drug discovery 2013 8(2) 142-168.
2010 Guan J Insulin-Like Growth Factor -1 (IGF-1) Derived Neuropeptides, a Novel Strategy for the Development of Pharmaceuticals for Managing Ischemic Brain Injury. CNS Neurosci Ther. 2010 Mar 4 17(4) 250-5.
2010 Guan J, Zhang R, L Dale Gandar and Vickers M. NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat. Beh Brain Research 210, 221-228.
2009 Guan J and Gluckman P. Endogenous small neuropeptides and their analogues: a novel strategy for the development of pharmaceuticals for neurological conditions. invited review by British Journal of Pharmacology 157, 881-891.
2009 Shapira S, Mathai S, Zhang R and Guan J Delayed peripheral administration of the N-terminal tripeptide of IGF-1 (GPE) reduces brain damage following microsphere induced embolic damage in young adult and aged rats. Neuroscience Letter 454 (1) 53-57.
2008 Jacobson L, Zhang R, Elliffe D, Chen C, Mathai S, Mccarthy D, Waldvoge H and Guan J. Co-relation of cellular/vascular changes and spatial memory during aging in rats Experimental Gerontology 43, 928-938.
2008 Guan J Insulin-like growth factor-1 and its derivatives: potential pharmaceutical application for ischemic brain injury. Recent Patents on CNS Drug Discovery 3(2):112-27.
2007 Guan J, Mathai S, Harris P, Brimble M, Wen JY Zhang R and Gluckman P Peripheral administration of a novel diketopiperazine, NNZ 2591 prevents brain injury and improves somatosensory-motor function following hypoxia-ischemia in adult rats. Neuropharmacolocy 53: 749-762.
2007 Svedin P, Guan J*(co-responding author), Mathai S, Zhang R, Wang XY, Hagberg H and Mallard C Delayed peripheral administration of a GPE analogue induces astrogliosis and angiogenesis and reduces inflammation and brain injury following hypoxia-ischemia in the neonatal rat. Developmental neuroscience 29: 393-402.
2004 Guan J, Thomas G B, Lin H, Matai S, Bachelor D C, George S, Fernandez J and Gluckman PD Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor –1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats. Neuropharmacology Vol 47 (6): 892-903.
2004 Krishnamurthi R, Stott S, Maingay M, Faull RLM, Mccarthy D, Gluckman PD and Guan J. N-terminal tripeptide of insulin-like growth factor –1 (GPE) improves functional deficits after 6-OHDA lesion in rats. NeuroReport 15(10); 1601-1604.
2003 Guan J, Bennet L PD Gluckman and Gunn AJ, Insulin-like growth factor-1 and the ischemic brain. Progress in Neurology 70 (6), 443-462.
2001 Guan J, Gunn AJ, Sirimanne S, Tuffin J, Gunning M, Clark R and Gluckman PD. The window of opportunity for neuronal rescue with insulin-like growth factor (IGF-1) after hypoxia-ischemia (HI) in rats is critically modulated by cerebral temperature during recovery. Journal Cerebral Blood Flow & Metabolism 20(2) 513-519, 2001.
1999, Guan J, Waldvogel H, Faull R, Gluckman P and Williams C The effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate in different regions following hypoxic-ischemic brain injury in adult rats. Neuroscience 89: 649-659.
1999, Saura J, Gatti S, Skinner S, Curatolo L, Peeters C, Williams C, Guan J, Dragunow M, Post C and Gluckman P Neuroprotective effects of Gly-Pro-Glu, the N-terminal tripeptide of IGF-1 in the hippocampus. NeuroReport 10:161-164.
1998, Gluckman, P.D. Guan, J., Williams, C., Scheepens, A., Zhang, R., Bennet, L. and Gunn, A. Asphyxial brain injury - the role of the IGF system. Molecular and Cellular Endocrinology 140, 95-99.
1996, Guan J, Williams CE, Skinner SJM, Mallard EC and Gluckman PD The effects of IGF 1, IGF 2 and des IGF 1 on neuronal loss after hypoxic ischemic brain injury in adult rats: evidence for a role for IGF binding proteins. Endocrinology 137(3): 893-898.
1993, Guan J, Williams CE, Gunning M, Mallard EC and Gluckman PD The effects of IGF 1 treatment after hypoxic ischemic brain injury in adult rats. J Cereb Blood Flow Metabolism 13:609 616.
1993, Gluckman PD, Guan J, Beilharz EJ, Klempt ND, Klempt M, Miller O, Sirimanne E, Dragunow M and Williams CE The role of the insulin like growth factor system in neuronal rescue. Ann N Y Acad Sci 692:138 148.
1992, Gluckman PD, Klempt ND, Guan J, Mallard EC, Sirimanne E, Dragunow M, Klempt M, Singh K, Williams CE and Nikolics K A role for IGF 1 in the rescue of CNS neurons following hypoxic ischemic injury. Biochem Biophys Res Commun 182:593 599
2021 Singh-Mallah G, Ardalan M, Singh K, Kang D, Mcmahon C, Mallard C and Guan J. Maternal cyclic glycine proline administration improves memory, astrocyte-associated vascular remodelling and glutamate trafficking in the hippocampus of adult offspring in rats. Nutriti Neurosci 27;1-11.doi: 10.1080/1028415X.
2018 Guan J, Singh-Mallah G, Liu K, Shorten P, Thompson J, Mitchell E, Taylor R, Harris P, Brimble M, Thorstensen E and Murphy R. The role for autocrine regulation of IGF-1 in pregnancy related obesity, a potential biomarker for weight changes. Journal of Biological Regulators and Homeostatic agents 32(3): 11-25.
2017 Singh-Mallah G, McMahon CD, Guan J and Singh K Cyclic-glycine-proline promotes post-lactational involution in mammary glands of rats through inhibiting IGF 1 function. Journal of Cellular Physiology 232 (12) 3369-3383doi: 10.1002/jcp.25782.
2016 Singh-Mallah G, Singh K, McMahon CD, Harris P, Brimble MA and Guan J, Maternal-infantile transfer following oral administration of cyclic-glycine-proline in lactating rats and its effect on improving memory in the offspring. Endocrinology 157(8):3130-9.
2016 Gagandeep Singh-Mallah, Kuljeet Singh, Christopher D. McMahon, Paul Harris, Margaret A. Brimble, Eric Thorstensen, Jian Guan, Maternally Administered Cyclic Glycine-Proline Increases Insulin-Like Growth Factor-1 Bioavailability and Novelty Recognition in Developing Offspring, Endocrinology, Volume 157, Issue 8, Pages 3130–3139, https://doi.org/10.1210/en.2016-1189
2015 Guillermo R, Yang P, Zhang R, Vickers M, McJarrow P And Guan J. Supplementation of complex milk lipids during brain development promoted neuroplasticity but did not alter myelination and vascular density. Food and Nutrition Research 2015, 59: 25765.
2015 Guan J, MacGibbon A, Fong B, Zhang R, Liu K, Rowan A and McJarrow P. Long-term Supplementation of BSC, a Complex of Milk Lipids, During Post-natal Brain Development Improves Memory in rats. Nutrients 2015, 7, 4526-4541; doi:10.3390/nu7064526 (special issue: Nutrition in cognitive function).
2010 Gustavsson M, Hodgkinson S, Fong B, Norris C, Guan J, Krageloh C, Breier BH, Davison M, McJarrow P, Vickers MH. Maternal supplementation with a complex milk lipid during pregnancy and lactation alters neonatal brain lipid composition but has no effect on cognitive function in normal adult male rat offspring. Nutrition Research 30(4):279-89.
2009 Vickers MH, Guan J, Gustavsson M, Krägeloh CU, Breier BH, Davison M, Fong B, Norris C, McJarrow P, Hodgkinson SC Supplementation with a mixture of complex lipids derived from milk to young rats results in improvements in parameters related to growth and cognition. Nutrition Research 29, 423-435.